endophytic squamous proliferation

DEVIL is a rare form of squamous proliferation characterized by prevalent PIK3CA and HRAS mutations. Epub 2016 Jun 14. J Oral Pathol Med. This is a preview of subscription content, access via your institution. WebVerrucous carcinoma (also known as Ackerman tumor) is an uncommon exophytic low-grade well-differentiated variant of squamous cell carcinoma. Cancer. D, Patchy p16 immunostaining in a condyloma acuminatum (hematoxylin-eosin, original magnifications 40 [A], 400 [B], and 100 [C]; original magnification 100 [D]). Biopsy of a lesion in the right proximal pretibial region demonstrated an atypical endophytic squamous proliferation, consistent with SCC. Fleiss JL. Oral Surg Oral Med Oral Pathol Oral Radiol. Mitoses are rare and confined to the basal layer.25 A band of lymphocytic infiltrate is usually found at the base of the tumor (Figure 3, A). Among these three types of clavicipitaceous endophytes are different interactions with their plant hosts. Seborrheic keratoses that contain human papillomavirus are condylomata acuminata, MIB-1 immunostaining is a beneficial adjunct test for accurate diagnosis of vulvar condyloma acuminatum, P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction, Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: clinical significance and diagnostic implications, Detecting HPV in cutaneous lesions using anti-HPV antibody immunohistochemistry, Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature, Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions: analysis of 42 cases, Giant condyloma acuminata of the inguinal region, Giant condyloma acuminatum of the scrotum, bilateral groins, and suprapubic region: a treatment and reconstruction challenge, Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma, Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguished from giant condyloma (Buschke-Lwenstein tumour), Rapidly invasive Buschke-Lwenstein tumor associated with human papillomavirus types 6 and 52, Giant condyloma versus verrucous carcinoma: a case report, Morphologic and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinico-pathologic entity. 1997;84(2):1547. A, The papillae are of variable lengths and shapes, covered by irregular well-differentiated squamous epithelium. - 213.202.212.252. Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting. In Search of Nodular Gastric Antral Vascular Ectasia: A Distinct Entity or Simply Hyperplastic Polyps Arising in Gastric Antral Vascular Ectasia. B, Parakeratosis is compact with a characteristic orange hue or peach color. A, This lesion demonstrates verruciform acanthosis and marked hyperkeratosis. Mitotic activity is low and is confined to the lower third of the epithelium. doi: https://doi.org/10.5858/arpa.2018-0039-RA. Bookshelf [3], Endophytes may be transmitted either vertically (directly from parent to offspring) or horizontally (among individuals). JAAD Case Rep. 2019 Nov 20;5(12):1051-1054. doi: 10.1016/j.jdcr.2019.08.008. A systematic review. [55], Two strains of the endophytic fungi Pestalotiopsis microspora isolated from stems of plants from the Ecuadorian rainforest were shown in laboratory experiments to be able to digest polyurethane plastic as the fungus's sole carbon source in anaerobic conditions, although many other non-endophytic fungi have demonstrated this ability, and most isolates of endophytic fungi in this experiment could perform this to some degree. A, A small verrucous papule with marked hyperkeratosis. Br J Dermatol. 2007;138(5):64151. Learn more about Institutional subscriptions. [2] In exchange the endophyte receives carbon for energy from the plant host. These findings suggest that some cutaneous squamous proliferations on the legs of women with multiple lesions lack prominent cytologic atypia as well as TP53 mutations and might be more akin to keratoacanthoma than SCC or might represent a reactive phenomenon. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Thompson, L.D.R., Fitzpatrick, S.G., Mller, S. et al. 2008;58(1):1517. The keratinocytes are bland and without koilocytic change. Mller S. Oral lichenoid lesions: distinguishing the benign from the deadly. Verruciform xanthomas are well-demarcated, yellowish-orange papules or plaques with verruciform surfaces ranging from 0.2 to 2 cm in diameter.89 Not surprisingly, the clinical morphology often raises concern for condyloma acuminatum or verrucous carcinoma.89,90 In a study of 10 vulvar verruciform xanthomas, all were associated with vulvar inflammatory or neoplastic conditions including lichen sclerosus, lichen planus, Paget disease, and radiodermatitis.89 Although HPV has been proposed in the past as the etiologic agent, multiple studies have failed to confirm a causal relationship.9193 Based on its benign nature and association with various diseases, it is now widely believed that verruciform xanthoma represents a mucocutaneous reaction to localized trauma and chronic inflammation.94. A, A warty squamous cell carcinoma shows an irregular verruciform architecture with conspicuous fibrovascular cores. [39] Non-systemic or transient endophytes on the other hand vary in number and diversity within their plant hosts under changing environmental conditions. A, An exophytic and endophytic verrucous squamous proliferation with a bulbous, pushing base. The rest of the keratinocytes lack cytologic atypia and mature orderly toward the surface. Indian J Dent Res. Careers. The 14 remaining tumors had more prominent cytologic atypia and remained classified as SCC. 8600 Rockville Pike Condyloma acuminatum is caused by HPV infection, with HPV types 6 and 11 being the most prevalent.5 HPV 6 and 11 belong to the low-risk HPV group, which essentially has no risk for malignant progression. The author has no relevant financial interest in the products or companies described in this article. Amongst these are relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma, which are underrecognized by surgical pathologists. Oral Oncol. For example, plant chemical signals have been shown to activate gene expression in endophytes. [66] Also, compounds from the marine fungus Nigrospora sp. Weba solid nodular form, which is largely endophytic with solid, lobulated masses of epithelium 4. an uncommon cystic type, with irregular clefts within the tumor and the formation of Fungal hyphae have been seen growing either flattened or wedged against plant cells. The case for antiherbivore defences", "Exploitation of endophytes for sustainable agricultural intensification", https://en.wikipedia.org/w/index.php?title=Endophyte&oldid=1141734599, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 26 February 2023, at 14:41. Of these subtypes, the endophytic tumours have the worst prognosis because of their invasiveness and higher frequency of Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trials. An official website of the United States government. Extraoral lesions are rare and usually arise on the vulva, penis, scrotum, and extremities.88 Most patients present with a solitary lesion, although coexistence of multiple lesions can occur. J Am Acad Dermatol. These papillae are surmounted by columns of parakeratosis (church spire parakeratosis), whereas the valleys between the papillae show hypergranulosis (Figure 7, B). Semin Diagn Pathol. Oral Dis. J Oral Pathol Med. Koilocytes containing enlarged and irregular nuclei, perinuclear halos, and coarse keratohyalin granules may be found in the granular and upper spinous layers. 2018;12(4):50010. Proliferative verrucous leukoplakia and field cancerization: report of a case. 2021 Jan;48(1):184-191. doi: 10.1111/cup.13861. 2017;83(5):58593. [59] Several isolates from the ascomycota Pestalotiopsis sp. CAS Head and Neck Pathol 15, 572587 (2021). [68] Epichlo endophytes are being widely used commercially in turf grasses to enhance the performance of the turf and its resistance to biotic and abiotic stresses. Oral Oncol. [20] Specific endophyte species can also stimulate root growth by increasing the flux of auxin to where the endophyte is. Figure 2Giant condyloma acuminatum. The papules have a median diameter of 0.7 cm according to one study and may be flat-topped or slightly verruciform, commonly mistaken for condyloma acuminatum on clinical examination.5254 Most patients are young adults in the third and fourth decades of life.53,54 Similar to HSIL, bowenoid papulosis is associated with high-risk HPV, particularly HPV 16.53,55 However, as progression to invasive SCC is exceptional, treatment options often include simple excision as well as local destructive modalities such as imiquimod and photodynamic therapy, although recurrence is common.53,5660 A small percentage of cases may regress spontaneously.53 A DNA ploidy study showed an intermediate malignancy grade between that of Bowen disease and SK, suggesting it to be a low-grade SCC in situ.61 Patients with bowenoid papulosis are at increased risk of developing external anogenital SCC and cervical neoplasia, and therefore warrant clinical surveillance on a regular basis.62,63, The histopathologic features of bowenoid papulosis overlap significantly with those of basaloid HSIL (Bowen disease).52 The lesions are acanthotic and may appear psoriasiform or slightly verruciform (Figure 6, A). Upadhyaya JD, Fitzpatrick SG, Islam MN, Bhattacharyya I, Cohen DM. These findings suggest that some cutaneous squamous proliferations on the legs of women with multiple lesions lack prominent cytologic atypia as well as TP53 mutations and might be more akin to keratoacanthoma than SCC or might represent a reactive phenomenon. Objective: Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;30(s1):S5467. which was first harvested from the plant Bontia daphnoides. sharing sensitive information, make sure youre on a federal Non-clavicipitaceous endophytes are divided into class 2, 3 and 4. Compared to condyloma acuminatum, the fibrovascular cores in papillary SCC are more irregular, and the tumor base is ragged (owing to stromal invasion) as opposed to round.37,51 It also differs from condyloma acuminatum and warty/warty-basaloid squamous neoplasms by the absence of koilocytes (Figure 5, B). 2007;43(3):22431. B, Many of the papillae have pointed tips surmounted by church spire parakeratosis. There was a belief that plants were healthy under sterile conditions and it was not until 1887 that Victor Galippe discovered bacteria normally occurring inside plant tissues. 2019;13(1):1624. [10] Endophytes may become active and reproduce under specific environmental conditions or when their host plants are stressed or begin to senesce, thereby limiting the amount of carbon provided to the endophyte. Verrucous hyperplasia of the oral mucosa. Downward epithelial proliferation for at least three times the normal thickness of the epithelium was considered bulky endophytic proliferation. These interaction range from pathogenic to symbiotic and symptomatic to asymptomatic. [59] Three triterpenes were found in the endophyte Xylarialean sp., all three of these compounds displayed mild cytotoxic effects on tumor cells. 2014;117(4):51120. Conspicuous fibrovascular cores and an infiltrative, rather than broad pushing, tumor base further distinguish papillary SCC from verrucous carcinoma. Approximately 40% of warts in the genital area of young girls are VV (positive for HPV 2) while the rest are condylomas (positive for HPV 6 or 11).70 The clinical morphologies of VV and condyloma acuminatum are similar in that both are exophytic and verrucous papules, but VV tends to be more hyperkeratotic than condyloma acuminatum. Angulated tumor nests infiltrate the underlying stroma. Is alveolar ridge keratosis a true leukoplakia? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Plant-microbe interactions are not strictly mutualistic, as endophytic fungi can potentially become pathogens or saprotrophs, usually when the plant is stressed. [18], There is evidence that plants and endophytes engage in communication with each other that can aid symbiosis. Celentano A, Glurich I, Borgnakke WS, Farah CS. Clavicipitaceous and non-clavicipitaceous, "An Archaic Approach to a Modern Issue: Endophytic Archaea for Sustainable Agriculture", "The Hidden World within Plants: Ecological and Evolutionary Considerations for Defining Functioning of Microbial Endophytes", "Defining the Genetic Basis of PlantEndophytic Bacteria Interactions", Creative Commons Attribution 4.0 International License, "Exploring the evolutionary ecology of fungal endophytes in agricultural systems: using functional traits to reveal mechanisms in community processes", "Experimental evidence of microbial inheritance in plants and transmission routes from seed to phyllosphere and root", "A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review", "Fungal endophytes and their interaction with plant pathogens: a review", "In planta regulation of extension of an endophytic fungus and maintenance of high metabolic rates in its mycelium in the absence of apical extension", "Chemical ecology of endophytic fungi: origins of secondary metabolites", "Increased Biomass of Nursery-Grown Douglas-Fir Seedlings upon Inoculation with Diazotrophic Endophytic Consortia", "An In vitro Study of Bio-Control and Plant Growth Promotion Potential of Salicaceae Endophytes", "Endophyte Effects on Photosynthesis and Water Use of Plant Hosts: A Meta-Analysis", "Salicaceae Endophytes Modulate Stomatal Behavior and Increase Water Use Efficiency in Rice", "Root ethylene signalling is involved in Miscanthus sinensis growth promotion by the bacterial endophyte Herbaspirillum frisingense GSF30T", "Endophytic root colonization of gramineous plants by Herbaspirillum frisingense", "Fungal endophytes: diversity and functional roles", "Mycorrhizal ecology and evolution: the past, the present, and the future", "Bacterial endophytes in agricultural crops and their role in stress tolerance: a review", "Bioprospecting for microbial endophytes and their natural products", "Endophytic fungi: a reservoir of antibacterials", "Can naturally-occurring endophytic nitrogen-fixing bacteria of hybrid white spruce sustain boreal forest tree growth on extremely nutrient-poor soils?

How Long Are 911 Calls Kept In Texas, Blackstone 17 Grease Cup, Sam Smith Tour Dates 2022, Articles E